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Tramadol's Chemistry

Chemical formula = C16H25NO2

Molar mass = 263.4 g/mol

Chemical name = (±)cis-2- [(dimethylamino)methyl]-1- (3-methoxyphenyl) cyclohexanol hydrochloride

Structural formula

Colour = White to off-white

Odour = Odourless

Melting Point = 180-184°C

ITS COMPOSITION..

  • Micro crystalline cellulose
  • Magnesium stearate
  • Pregelatinised starch
  • Iron oxide
  • Indigo carmine
  • Titanium dioxide
  • Gelatin
  • Propylene glycol
  • Black iron oxide
  • Shellac glaze

Its shell-life is 3 years.

ALERT !!

  • Do not store tramadol tablets in temperature above 30°C.
  • Keep its container tightly packed.

YES !! TRAMADOL HAS PASSED THE
PRECLINICAL SAFETY TEST..



On rats.

Tramadol was administered orally in a few rats for 5-25 weeks. No substances-related changes were observed in any clinico-chemical , histological and haematological investigations. oral doses of 20mg/kg were tolerated by rats. Dosage above 50mg/kg/day cased hazardous affects and a rise in neonatal mortality. Baby rats suffered delayed vaginal and eye opening and ossification disorder. High doses did not affect male fertilily but inhibited the female pregnancy rate.

On dogs.

Tramadol was administered orally in a few dogs for 12 months . High doses caused restlessness, salivation, convulsions, and weight loss. Dogs easily tolerated 20mg/kg.

Tramadol is classified as Non-mutagenic.

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